Nikki Glaser and David Spade Bring Stand-Up’s Sharpest Double Bill to Las Vegas

The Colosseum at Caesars Palace has hosted Celine Dion, Elton John, and Adele. This Friday and Saturday, it belongs to comedy. Nikki Glaser and David Spade co-headline two nights at the 4,100-seat venue on May 22 and 23, with tickets starting at $73 on Spotlight. It’s the second block of their six-date 2026 residency, and for anyone browsing stand-up shows in Las Vegas this Memorial Day weekend, this is the headliner.

Two Career Peaks, One Colosseum Stage

Glaser is in the middle of a career run that started with her breakout set at Netflix’s The Roast of Tom Brady in 2024 and hasn’t slowed down. She hosted the Golden Globes solo in January 2025, the first solo female host in the ceremony’s history, and came back to host again in January 2026 to reviews that Rolling Stone called “a master class.” The New York Times named her Comedian of the Year in 2024. TIME put her on the 100 Most Influential People list in both 2025 and 2026. Her latest Hulu special, Nikki Glaser: Good Girl, dropped less than a month ago on April 24. She’s currently on The Stunning Tour through the rest of the year, with a third Golden Globes hosting gig locked in for January 2027.

Spade brings a different kind of edge. His “Hollywood Minute” segment on Saturday Night Live in the early ’90s made deadpan sarcasm appointment television. He earned Emmy and Golden Globe nominations for Just Shoot Me!, starred in Tommy Boy and Joe Dirt, voiced Kuzco in Disney’s The Emperor’s New Groove, and kept touring through all of it. Recent specials include Nothing Personal on Netflix and Dandelion on Prime Video. He co-hosts the Fly on the Wall podcast with Dana Carvey, pulling behind-the-scenes stories from their SNL years into weekly episodes.

Together, they tested the co-headline format at The Venetian in 2025, where back-to-back May dates drew more than 3,500 fans. The Colosseum upgrade for 2026 reflects that demand.

What to Expect Inside the Room

The show runs about 90 minutes with no intermission. Both comedians perform full sets in a true co-headline format. All shows start at 8 p.m. and the production is open to ages 12 and up.

Their styles contrast in a way that keeps the energy moving. Glaser’s material is confessional and rapid-fire, built around dating, self-image, and sharp cultural observations. Spade’s comedy runs drier and more observational, loaded with Hollywood stories and sarcastic crowd work. You get two distinct tones without either act stepping on the other’s rhythm.

The Colosseum itself adds to the experience. Built in 2003 at a cost of $95 million, the venue uses a modular seating system designed for clean sightlines from every seat. Jerry Seinfeld has headlined the room since 2003. Ellen DeGeneres, Dave Chappelle, and Kathy Griffin have all worked the same stage. Seinfeld still performs there regularly (from $123 on Spotlight), making it the most proven comedy room on the Strip at this scale.

Dates, Pricing, and the September Return

The May 22 and 23 dates land on Friday and Saturday of Memorial Day weekend. Tickets range from $73 to $98 on Spotlight, with seating options across the Colosseum’s tiered layout. A third pair of dates returns September 4 and 5 over Labor Day weekend for anyone who misses the May run.

For anyone checking Las Vegas shows this weekend, the Colosseum stacks up well across the holiday. Rod Stewart’s Encore Shows pick up at the same venue on May 27 (from $76). Kelly Clarkson holds residency dates there as well (from $89). Blake Shelton wraps his Colosseum run on May 24 (from $112). One venue, four headliners, one long weekend.

Get Your Seats

Ninety minutes of sharp stand-up from two of comedy’s biggest active names, inside the same room that launched the modern Las Vegas residency, at a price that starts below $75. Browse dates, pick your section from the interactive seating map, and lock in tickets on Spotlight Vegas.